First line therapy in smoking dependence:

(Ref: Katzung, 14th ed. pg. 584)Treatment of smoking dependence:* First line: Nicotine replacement therapy (gum, patch, inhaler).* Bupropion and Varenicicline (Nicotine receptor agonist): Also, first line. Considered more effective.* 2nd line: Clonidine and Nortryptiline* Rimonabant: Cannabinoid receptor inverse agonist. Withdrawn due to increased depression and suicide risk.