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Surgery General 79fbd996

Which of the following antihistaminic is free of arrhythmogenic potential?

A
Terfenadine
B
Fexofenadine
C
Loratadine
D
Ebastine
High-Yield Explanation
Loratidine Loratidine is paially metabolized by CYP3A4 to an active metabolite with a longer T1/2 of 17 hours but in contrast to terfenadine/astemizole, it has not produced cardiac arrhythmia in overdose.

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