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Pharmacology Central Nervous system 79db9540

Which of the following statement is not true about domperidone?

A
It rarely causes extrapyramidal side effects
B
It is a D2 receptor antagonist
C
Its antiemetic efficacy is higher than metoclopramide
D
It causes loose stool
High-Yield Explanation
Domperidone is an antiemetic which is classed under prokinetic drugs. It is a D2 antagonist; But it crosses blood brain barrier poorly - hence extrapyramidal side effects are rare, hyperprolactinemia can occur. Its antiemetic efficacy is LOWER than metoclopramide. Side effects are much less than with metoclopramide; dry mouth, loose stools, headache, rashes, galactorrhea, cardiac arrhythmias on rapid IV injection.Ref:KD Tripathi 8th ed.

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