A child died soon after bih. On examination there was hepatosplenomegaly and edema all over body. Most probable diagnosis in -

Ans. is 'b' i.e., alpha-thalassemia o Out of the given 4 types of hemolytic anemias only alpha thalassemia is able to give rise to such severe presentation at bih. In all other conditions the newborn is either normal or has mild jaundice.