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Medicine Chronic Kidney Disease and Uremia 78c145e7

Decreased erythropoietin levels are seen in:

A
End stage renal disease
B
Heart failure
C
Polycytic kidney disease
D
Advanced Liver failure
High-Yield Explanation
Ans: A (End stage renal disease) Ref: Harrison's Principles of Internal Medicine, 18th ed.Explanation:End-stage renal disease is replaced by the term stage 5 CKD (Chronic kidney disease)."The primary cause in patients with CKD is insufficient production of erythropoietin (EPO) by the diseased kidneys " Ref: Harrison.Causes of Anemia in CKDRelative deficiency of erythropoietinDiminished red blood cell survivalBleeding diathesisIron deficiencyHyperparathvroidism/bone marrow fibrosisChronic inflammationFolate or vitamin B12 deficiencyHemoglobinopathyComorbid disease

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