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Pharmacology General 78a3ba1c

Difference between rantidine & cimetidine is ?

A
Ranitidine is 5 times more potent than cimetidine
B
Cimetidine is 5 times more potent than ranitidine
C
Ranitidine has androgenic action
D
Ranitidine more markedly inhibits hepatic metabolism
High-Yield Explanation
Ans. is 'a' i.e., Ranitidine is 5 times more potent than cimetidine Ranitidine has several desirable features compared to cimetidine: 5 times more potent than cimetidine. No antiandrogenic action, does not increase prolactin secretion or spare estradiol from hepatic metabolism - no effect on male sexual function or gynaecomastia. Lesser permeability into brain. Less marked inhibition of hepatic metabolism of other drugs. Overall incidence of side - effects is lower.

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