Treatment of choice of stage III CIN in 40-year-old female is:

As discussed in preceding text - management options in CIN are Ablative techniques like cryosurgery, laser vaporization therapy Excisional methods - like LEEP (Loop electro excisional procedure) or LLETZ (large loop excision of transformation zone), condition surgery Hysterectomy In general, the major drawback of ablative procedures is - it destroys the tissue and so no tissue specimen is available for additional histologic evaluation during follow-up. Cryotherapy: It should be considered only if. There is a minor degree of CIN localized and it is "This method is ideal for minor degrees and localized CIN"  - Dutta 6th /ed p 327 Thus in this patient - cryotherapy will not be done as she has CIN III Laser ablation: Rarely used in practice. Used only if CIN extends to vaginal fornices. Remember Most early CIN is now managed expectantly so the need for ablation is decreasing." Hysterectomy: As far as hysterectomy is concerned - it is taken as too radical a procedure for management of CIN and is reserved for special circumstances like recurring CIN - Recent management says whether the patient is young or old -CIN111 should be managed by LEEP/LLETZ.