In unconjugated hyperbilirubinemia, the risk of kernicterus increases with the use of –

The administration of sidfonamides to newborn infants, especially if premature, may lead to the displacement of Bilirubin from plasma albumin. In newborn infants, free Bilirubin can become deposited in the basal subthalamic nuclei of the brain 'causing an encephalopathy called kernicterus. Sulfonamides should not be given to pregnant women near term because these drugs pass through the placenta and are secreted in milk. Kernicterus is due to unconjugated hyperbilirubinemia.