Granulomatous disease(s) is/ are (A)Lichen planus (B)Histoplasmosis (C)Sarcoidosis (D)Lupus erythromatosis (E)Asbestosis
High-Yield Explanation
Asbestosis Q, & SLE cause alveolis, intersal inflammaon & fibrosis, not granulomatous lesion (HI 7/1643, H16/1555) SLE pulmonary manifestation (H17/2078)
"The most common pulmonary-' manifestation of SLE is pleuritisR with or without pleural effusion.
Life threatening pulmonary manifestation include interstitial inflammation leading to fibrosis,
shrinking lung syndrome 1 ' & intraalveoiar hemoorrhage."
It is characterized by an accumulation of T lymphocyte, macrophage & epithelioid cells organized into discrete structures (granuloma) in lung parenchyma.
These lesions can progress to fibrosis Many paents with granulomatous lung disease remain free of severe impairment of lung funcon,
or, when symptomac they improve aer treatment. Lung Response : Granulomatous (H19th/1708,17th/i643) Known Cause Hypersensivity
pneumonis Q (organic dust) Inorganic dusts : beryllium Q , silica Unknown cause Sarcoidosis' 3 Langerhan's cell granulomatosis Wegener's granulomatosis'
3 Allergic granulomatosis of Churgstrauss disease Bronchocentric granulomatosis Lymphomatoid granulomatosis "3 Granulomatous vasculides Granuloma of Lung:
Causes (Dahnert 5th/489) 1. Sarcoidosis Q 2. Non Sarcoid granulomatous disease Infecons Bacterial: TB, gumma Opportunisc:
Crytococcosis Parasic : Dirofilaria immis (dog heartworm) Fungal: Histoplasmosis^, Coccidioidomycosis' 3 , nocardiosis Nonifecons Foreign body :
Talc, beryllium 13 , algae, pollen, cellulose, lipids, abuse of nasally inhaled drugs, aspiraon of medicaon Angiocentric lymphoproliferave disease Vasculides
Extrinsic allergic alveolis Langerhans cell hisocytosis Pulmonary' hyalinizing granuloma