Acute osteomyelitis of long bones commonly affects the:

Metaphysis of long bone is the earliest and most common site involved in osteomyelitis. It stas in metaphysis because of: Defective phagocytosis in metaphysis (Inherently depleted Reticuloendothelial System Rich blood supply Hair pin bend of metaphyseal vessels (leads to vascular stasis and decreased oxygen tension) Metaphyseal hemorrhage due to repeated trauma (acts as culture media)