Cardiac or central nervous system toxicity may result when standard lignocaine doses are administered to patients with circulatory failure. This may be due to the following reason :

Question

Accepted Answer

Lignocaine concentration is initially higher in relatively well perfused tissues such as brain and heart.

Answer

Histamine receptors in brain and heart get suddenly activated in circulatory failure

Answer

There is a sudden outburst of release of adrenaline, noradrenaline and dopamine in brain and heart

Answer

Lignocaine is converted to a toxic metabolite due to its longer stay in the liver.

Cardiac or central nervous system toxicity may result when standard lignocaine doses are administered to patients with circulatory failure. This may be due to the following reason :

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