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Pharmacology Autacoids 76025377

For pain control in a patient having history of G I bleeding, which of the following is given?

A
Nimesulide
B
Ibuprofen
C
Rofecoxib
D
Pentazocin
High-Yield Explanation
SELECTIVE COX-2 INHIBITORS- Rofecoxib,etoricoxib,celecoxib They cause little gastric mucosal damage; the occurrence of peptic ulcer and ulcer bleeds is clearly lower than with traditional NSAIDs. They do not depress TXA2 Production by platelets (COX-I dependent); do not inhibit platelet aggregation or prolong bleeding time but reduce PGI2 production by vascular endothelium. They increase the risk of cardiovascular events ESSENTIALS OF MEDICAL PHARMACOLOGY;7TH EDITION;KD TRIPATHI;PAGE NO 205

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