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Biochemistry General 75f913e3

Alcohol causes hypoglycemia due to ?

A
Decreased gluconeogenesis
B
Decreased NADH
C
Decreased lipogenesis
D
Decreased glycogenesis
High-Yield Explanation
Ans. is 'a' i.e., Decreased gluconeogenesisExcess intake of alcohol leads to excessive production of NADH with a concomitant decrease in NAD+.This causes following metabolic alterations :-i) The increase availability of NADH ours the reduction of pyruvate to lactate and oxaloacetate to malate and decreasing its availability for gluconeogenesis and decrease synthesis of glucose. This results in Hypoglycemia.ii) Increased ratio of NADH/Nad+ inhibits p-oxidation of fatty acids and citric acid cycle and promotes lipogenesis, triacylglycerol synthesis and cholesterol synthesis from acetyl CoA.iii) Increased lactic acid production causes lactic acidosis and hyperuricemia.iv) Accumulation of lipid in various tissues causes fatty liver, fatty myocardium etc.

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