Malignancy is typically associated with disordered differentiation and maturation. Which of the following mentioned option best describe anaplasia?

Lack of Differentiation is called Anaplasia. Hepatic tumors synthesizing bile - The actual function of the hepatocytes is to produce bile.(Normal state) Skin tumor producing keratin pearl - Skin has the presence of Squamous epithelium and that is going to have the presence of keratin pearl (Again normal) Bronchial epithelium cell producing keratin pearl- The ciliated columnar epithelium of the bronchi is producing something which is the function of squamous epithelium, this is referred as disordered function which signifies anaplasia. Colonic tumor cell producing mucin- colonic epithelium is columnar epithelium and it is its normal function to produce mucin.