Full 2L QBank
Pharmacology All India exam 75c82486

Benzodiazepine binding site on GABA receptors is on ?

A
y-subunit
B
a-subunit
C
b-subunit
D
d-subunit
High-Yield Explanation
[Ref: Goodman/Gillman REF : katzung pharmacology : 14th ed The exact subunit structures of native GABA receptors are still are unknown, but it is thought that most GABA receptor are composed of alpha, beta & gamma subunits that Coassemble with some unceain stoichiometry. Binding site of GABA is on beta-subunit. Benzodiazepine site is located on the a subunit but the stabilization or completion of that site in the assembled. Structure also requires the y subunit.

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