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Medicine Endocrinology 75706930

A 32-year-old woman is evaluated in the clinic for symptoms of polyuria and polydipsia. She has no significant past medical history and her only medication is the oral contraceptive pill.Her physical examination is entirely normal. Urine and serum biochemistry investigations are suggestive of central diabetes insipidus (DI). Which of the following is the most likely finding on magnetic resonance imaging (MRT) of the brain?

A
hypothalamic tumor
B
hyperintense signals in the cerebral cortex
C
agenesis of the corpus callosum
D
lack of hyperintense signals from the posterior pituitary
High-Yield Explanation
Because DI is usually caused by destruction, or agenesis, of the posterior pituitary, its normal signaling is lost. Pituitary DI can also result from trauma, tumors (both primary and secondary), granulomas, infections, inflammatory diseases, chemical toxins, congenital malformations, and genetic disorders.Depending on the cause, the MRI may demonstrate other associated findings.

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