The mechanism of action by which pyrantel pamoate is effective for the treatment of Necator americanus (hookworm) disease is.

Pyrantel pamoate is an antihelminthic that acts primarily as a depolarizing neuromuscular blocker. In ceain worms, a spastic neuromuscular paralysis occurs, resulting in the expulsion of the worms from the intestinal tract of the host. Pyrantel also exes its effect against parasites release of acetylcholine andinhibition of cholinesterase.