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Medicine Diabetes Mellitus 74b0309a

Which sulfonylurea drug has the highest insulinotropic potency?

A
Glyburide
B
Glipizide
C
Glimepiride
D
Gliclazide
High-Yield Explanation
Sulfonylureas act on receptors in pancreatic beta cells resulting in closure of potassium cells. This results in depolarization of Beta cell and release of insulin. Glyburide has the highest affinity/ insulinotropic action while tolbutamide has least affinity.

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