Medicine Nephrotic and Nephritic syndrome 747a925c First line treatment of RPGN is? A Wait and watch B Sirolimus C Methylprednisolone D Plasma exchange High-Yield Explanation * For management of acute GN/ RPGN give 500-1000 mg methylprednisolone while awaiting biopsy results. * Consider plasmapheresis for fuher treatment based on underlying disease.