Which of the following is the most effective treatment of severe malaria?

Aesunate has, therefore, become the drug of choice for all patients with severe malaria everywhere. Aesunate is given by IV injection but can also be given by IM injection. Aemether and the closely related drug aemotil (aeether) are oil-based formulations given by IM injection; they are erratically absorbed and do not confer the same survival benefit as aesunate. (Harrison's Principles of internal medicine, 20 th edition, page 1701)