Basic abnormality in a case of nephrotic syndrome is: September 2008

Ans. B: Proteinuria Nephrotic syndrome (NS)/ nephrosis is defined by the presence of nephrotic-range proteinuria, edema, hyperlipidemia, and hypoalbuminemia. Heavy proteinuria (more than 1 gm/metre square per day) is the basic abnormality leading to the hypoalbuminemia (serum albumin below 2.5 g/ dL)