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Pharmacology General 73667260

The phase I reactions of drug metabolism include the following except:

A
Hydrolysis
B
Reduction
C
Oxidation
D
Conjugation
High-Yield Explanation
Biotransformation reactions can be classified into:  Nonsynthetic/Phase 1/Functionalization reactions:  A  functional group (- OH, -COOH, -CHO, H2, - SH) is generated or exposed- metabolite may be active or inactive.  Synthetic / Conjugation / Phase lI reactions:  An endogenous radical is conjugated to the drug- metabolite is mostly inactive; except few drugs, e.g. glucuronide conjugate of morphine and sulfate conjugate of minoxidil are active. Certain drugs already have functional groups and are directly conjugated, while others undergo a phase I reaction first followed by a phase II reaction.

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