Microbiology Immunology 7366609d Marker of chronic inflammation is? A IL-1, IL-6 B IL-1, TNF C IL-6, TNF D IL-12, IFN-g High-Yield Explanation Interleukin 12 and Interferon-gamma are the major markers of chronic inflammation. REF:Textbook of microbiology, Ananthanarayan, and Paniker.