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Pathology Genetics 72f6d689

In an Autosomal Dominant disorder, mother is affected but is heterozygous. Father is normal. What are the chance of disease in children?

A
50% affected
B
25% affected
C
75% affected
D
All affected
High-Yield Explanation
Ans. (a) 50% affected(Ref: Robbins 9th/pg 140; 8th/pg 140)In an Autosomal Dominant disorder, mother is affected but is heterozygous and father is normal.Therefore, the chances of disease in children is 50%

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