Chronotrophic means: March 2010

Ans. B: Drugs affecting hea rate Chronotropic effects are those drugs that change the hea rate. Chronotropic drugs may change the hea rate by affecting the nerves controlling the hea, or by changing the rhythm produced by the sinoatrial node. Positive chronotropes increase hea rate; negative chronotropes decrease hea rate. A dromotrope affects Atrioventricular node (AV node) conduction. A positive dromotrope increases AV nodal conduction, and a negative dromotrope decreases AV nodal conduction. A lusitrope is an agent that affects diastolic relaxation. Inotropes affects contractility of the hea. Chronotropic variables in systolic myocardial performance can be split left and right. Left sided systolic chronotropy can be appreciated as Aoic Valve open to close time. Right sided variables are represented by Pulmonary valve open to close time. Inveed as diastolic chronotropy, the variables are aoic valve close to open and pulmonic close to open time.