Which drug can be eliminated by nonenzymatic degradation-

(Refer: Morgan and Mikhail’s Clinical Anaesthesiology, 5th edition, pg no. 216, 269) The unique feature of atracurium is inactivation in plasma by spontaneous non-enzymatic degradation (Hofmann elimination) in addition to that by alkaline ester hydrolysis Consequently its duration of action is not altered in patients with hepatic/renal i9nsufficiency or hypodynamic circulation → preferred muscle relaxant for such patients as well as for neonates and the elderly Atracurium is metabolized to laudanosine that is responsible for seizures.