There is a mutation of a gene coding for the ryanodine receptors in malignant hyperthermia. Which of the following statements best explains the increased heat production in malignant hyperthermia?
High-Yield Explanation
Ryanodine receptors in sarcoplasmic reticulum act as calcium channels. The mutation of Ryanodine receptors causes it to release Ca++ into sarcoplasm uncontrollably resulting in high metabolism by the muscles. This causes malignant hyperthermia.