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Medicine General 712c11d7

Huntington's disease is due to the loss of :

A
Nigrostriatal dopaminergic neurons
B
Intrastriatal cholinergic neurons
C
Intrastriatal GABAergic neurons
D
Intrastriatal cholinergic and GABAergic neurons
High-Yield Explanation
Answer is D (Intrastrial cholinergic and GABAergic neurons): 'The repoed abnormality in Huntington's disease suggests a relative under activity of neurons containing gammaaminobutyric acid (GA BA) and acetylcholine ' - CMDT 2005 / 980 `There is severe loss of striatal neurons, the most dramatic changes being found in the caudate nucleus' - Robbins 7th/ 1394 (Caudate nucleus is pa of striatum)

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