Prions are best killed by

Ans. is 'c' i.e., Sodium hydroxide Incineration is apparently the only way of disinfecting prion-contaminated materials or tissues. Boiling or irradiation have no effect and even routine autoclaving (at 121degC) is not reliable. Therefore, where there is a risk of exposure, surgeons use disposable instruments. To sterilize reusable instruments, WHO currently recommends combined use of a strong solution of sodium hydroxide and extended autoclaving at 134degC. "Autoclaving at 134degC for 5 hrs or treatment with 2 N NaOH for several hours is recommended for sterilization ofprions". Harrison