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Physiology Muscle 70db0159

True about Duchenne's muscular dystrophy is:

A
It is an X- linked recessive disorder
B
Skeletal muscle wasting occurs due to abnormalities of the contractile filaments
C
Muscle wasting occurs in the pelvic region only
D
It is a form of titanopathy
High-Yield Explanation
Duchenne's muscular dystrophy (DMD) is an X-linked recessive disorder. (option A is correct.) There is a genetic defect in the dystrophin gene; it results in deficiency of the protein dystrophin in skeletal muscle Dystrophin is a large protein that is present on the intracellular surface of the sarcolemma, it makes dystrophin-glycoprotein complex.. In DMD, there is severe muscle wasting; death may occur from respiratory failure.

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