Most common complication of modified ECT
High-Yield Explanation
* Electro convulsive therapy (seizure) increases production of brain derived neurotrophic factor (BDNF)Q. Madsen proposed generation of new neurons in the hippocampus may be an impoant neurobiological element underlying the clinical effects of ECT. * ECT is most commonly indicated (-85% of all ECT) and most effective in treatment of major depression (with psychosis / delusions /or suicidal tendency)Q. ECT is indicated in psychotic (delusional) depressionQ because nihilistic delusions may induce suicidal tendency, whereas ECT is not indicated in neurotic depression (dysthynia), cyclothymiaQ. ECT may be useful in MDP (bipolar) in decreasing duration of depressive episode. ECT is not (or less) useful in chronic conditions like chronic schizophrenia (with negativ symptoms esp)Q. Use of ECT is not the first line (choice) of treatment in mania & schizophrenia (lithium & anti psychotics are mainstay of treatment). Panic disorder is also treated with drugs not ECT. REF : Oxford text book of psychiatry 3rd Ed.