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Physiology General 6faa7b66

Diffusion of lipid-insoluble substances across the cell membrane depends on all of the following except

A
Hydrated radius
B
Electrical charge
C
Lipid solubility
D
Shape
High-Yield Explanation
Ans: C. Lipid solubility(Ref: Principle of medicalphysiolog p. 712).Simple diffusion of lipid-soluble substancesThe rate of diffusion through the lipid bilayer of the cell membrane is directly propoional to the solubility of a substance in lipids.Therefore, molecules of substances like orygen, nitrogen, carbon dioxide, alcohol, steroid hormones and weak organic acids and bases, being lipid soluble, diffuse very rapidly through the lipid bilayer of the cell membrane.

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