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Anatomy General anatomy 6f6b53ff

Which is seen in chediak Higashi syndrome

A
Neutopenia
B
Defective microbial killing
C
Presence of large granules in neutrophils
D
All of the above
High-Yield Explanation
Ref Harrison 16/e p,353:,354, Robbins 9/e p238 Chediak Higashi syndrome: Autosomal recessive inheence Due to defect in lysosomal transpo protein LYST. Clinical feature include: primary immune deficiency, neutropenia , defective microbial killing,impaired chemotaxis,hypopigmentation, photophobia, nystagmus. Microscopic examination shows giant peroxidase positive inclusion in the cytoplasm of leukocytes

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