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Medicine Amyotrophic Lateral Sclerosis and other motor neuron diseases 6f3b56c0

Which of the following is FALSE regarding Neurofibromatosis inheritance:

A
Von Recklinghausen's Disease is due to defect in chromosome 17
B
Autosomal dominant type of inheritance
C
NF-2 - Musculoskeletal deformities is characterstic
D
NF-1 - Most common single gene disorder affecting human nervous system.
High-Yield Explanation
NEUROFIBROMATOSIS (NF) NF - 1/Von Recklinghausen's Disease NF-2/Bilateral acoustic neurofibromatosis Most common single gene disorder affecting human nervous system. Peripheral neurofibromatosis, is due to defect in chromosome 17. AD inheritance 100% penetrance Due to defect in long arm of chromosome 22. AD inheritance Musculoskeletal deformities absent 8th nerve vestibular schwannomas Meningioma occur in 50% cases. Note: Usually Skeletal disorders are Autosomal Dominant and Inborn errors of metabolism are autosomal recessive

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