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Pathology Disease of Infancy & Childhood 6dcd39f1

All are true about cystic fibrosis except?

A
Recurrent respiratory infections
B
Majority of males are infertile
C
Fasting hyperglycemia is a feature of early disease
D
Sweat chloride is >70 meq/1
High-Yield Explanation
Ans. (c) Fasting hyperglycemia is a feature of early disease(Ref: Refer Ans 7 & 10; Nelson 19th/pg 1996; Robbins 9th/pg 466-470; 8th/pg 465-470)Cystic fibrosis-related diabetes (CFRD)No diabetes is seen in CF patients younger than 10 yr while 40-50% show diabetes at >=20yr age;So diabetes is a late feature of CF, seen only in individuals who survive to adolescence & beyond.Patients with CFRD have features of both T1DM and T2DM.There is pancreatic damage leading to slowly progressive insulin deficiency, along with insulin resistance

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