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Pharmacology General 6d3f7755

Which one of the following substances is the most potent androgen -

A
Dihydroepiandrostendione
B
Dihydrotestosterone
C
Androstendione
D
Testosterone
High-Yield Explanation
Ans. is 'b' i.e., Dihydrotestosterone "Dihydrotestosterone is more active than testosterone - It binds more avidly with the cytoplasmic receptors, and this complex is more active than testosterone receptor complex in combining with DNA." o Dehydroepiandrosterone and androstenedione are weak androgen - Potency 1/20 to 1/30 of testosteone.

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