Ki 67 antigen is associated with carcinoma of:

PCNA is a nuclear protein associated with a DNA polymerase whose expression increases in phase G1 of the cell cycle, reaches its maximum at the G1/S interface, and then decreases through G2. Immunohistochemical staining for PCNA outlines the proliferating compaments in breast tissue. Good correlation is noted between PCNA expression and (a) cell-cycle distributions seen on flow cytometry based on DNA content, and (b) uptake of bromodeoxyuridine and the proliferation-associated Ki-67 antigen. Individual proliferation markers are associated with slightly different phases of the cell cycle and are not equivalent. PCNA and Ki-67 expression are positively correlated with p53 overexpression, high S-phase fraction, aneuploidy, high mitotic index, and high histologic grade in human breast cancer specimens, and are negatively correlated with estrogen receptor content. Ref: Schwaz's principle of surgery 9th edition, chapter 17.