Two weeks after birth, a baby has persistent tachypnea, tachycardia, diaphoresis, and cyanosis. Workup reveals a patent ductus arteriosus. This can be closed with the use of:

The nonsteroidal anti-inflammatory drug, indomethacin, is the drug of choice for closure of a patient ductus arteriosus in a premature infant with an isolated patient ductus arteriosus. For complex cardiac anomalies, which require a patient ductus arteriosus to sustain life until corrective surgery can be done, prostaglandin E1 can be administered to keep the ductus arteriosus open. The other choices are not indicated in patient ductus arteriosus.