Physostigmine was therapeuticallyused for the first time in treatment of glaucoma in 1877 by –

Laqueur Posselt and Reiman isolated nicotine from the leaves of Nicotiana tabacum. Ahlquist gave the hypothesis that adrenaline acts on different sets of receptors, later named as α and β. Sir James Black synthesized the first β-blocker, dichloroisoproterenol, and subsequently, propranolol.