Ophthalmology General 6c429237 Earliest manifestation of diabetic retinopathy is A Soft exudates/Cotton wool spot B Dot haemorrhage C Hard exudates D Microaneurysm High-Yield Explanation D i.e. Microaneurysm Microaneurysms are located in the inner nuclear layer and are the earliest and most characteristic ocular lesion Q of diabetic retinopathy.