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Pharmacology Prostaglandins 6c222a4a

Gastric irritation is least with following NSA1D: (PGI June 2008)

A
Diclofenac
B
Acetaminophen
C
Ibuprofen
D
Naproxen
High-Yield Explanation
Ans. B (Acetaminophen) "Gastric mucosal damageQ: Gastric pain, mucosal erosion/ ulceration and blood loss are produced by all MSAIDs to varying extents: relative gastric toxicity is a major consideration in the choice of MSAIDs. Paracetamol", a very weak inhibitor of COX is practically free of gastric toxicity and selective (misoprosto) administered concurrently with NSAIDsanatgonise their gastric toxicity"- KDT 6th/186Aspirin is acetylsalicylic acid KDT 6th/187

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