A 58-year-old man with a long-standing history of type 2 diabetes mellitus suffers a massive hemorrhagic stroke and expires. Examination of the pancreas shows hyalinization of many islets of Langerhans. Which of the following characterizes the material within the islets of Langerhans?
High-Yield Explanation
T2DM Amyloid is often present within islets of Langerhans, paicularly in patients over 60 years of age. Amyloid is derived from a polypeptide molecule known as amylin, which is secreted with insulin by b-cell. 20% of aged non-diabetic persons also have amyloid deposits in pancreas