A 10-year old child is undergoing squint surgery. He suddenly developed increased hea rate, arrhythmia, high fever, metabolic and respiratory acidosis on aerial blood gases and elevation of end tidal CO2. Which of the following would be the first agent of choice in the management of this condition?

Ans. a. Dantrolene Sudden development of increased hea rate, arrhythmia, high fever, metabolic and respiratory acidosis on aerial blood gases and elevation of end tidal CO, in a child undergoing squint surgery is highly suggestive of malignant hypehermia. Dantrolene would be the first agent of choice in the management of malignant hypehermia. "Malignant Hypehermia: Dantrolene is the only drug effective in reversing the symptoms and preventing the episode.