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Medicine Nephrotic and Nephritic syndrome 6bc3ffc1

All are true about Hemolytic uremic syndrome except?

A
Uremia
B
Hypofibrinogenemia
C
Thrombocytopenia
D
Positive Coombs test
High-Yield Explanation
Positive Coombs test is seen with autoimmune hemolytic anemia but in H.U.S microangiopathic hemolytic anemia is seen. The entrapment of platelets in micro-thrombi formed in small blood vessels leads to thrombocytopenia. The consumption of clotting factors due to initiation of coagulation cascade leads to hypofibrinogenemia. Hemolytic uremic syndrome- characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure which explains uremia.

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