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Anatomy Other topics and Adverse effects 6b6117ed

Which of the following provides the best explanation for neostigmine being preferred over physostigmine for treating Myasthenia gravis

A

It is better absorbed orally

B

It has longer duration of action

C

It is the additional direct on agonistic action on nicotinic receptor in the muscle end plate

D

It Penetrates blood brain barrier

High-Yield Explanation

Ref-KDT 6/e p103 Neostigmine is a quaternary ammonium derivative and is lipid insoluble. Its absorption from GIT penetration in the brain and cornea is much less than physostigmine . It produces additional action on NM receptor

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