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Pathology Bleeding disorder 6ab95bf9

Thrombotic event is seen in all of following except:

A
Paroxysmal nocturnal hemoglobinuria
B
Disseminated intravascular coagulation
C
Idiopathic thrombocytopenic purpura
D
Heparin induced thrombocytopenia
High-Yield Explanation
*PNH is seen due to PIGA gene defect - Pancytopenia Altered function of platelets - | risk of thrombosis Especially in cerebral & hepatic veins - | Moality *DIC is thrombo-hemorrhagic disorder *Heparin-induced thrombocytopenia has ab produced against platelet factor 4. Also associated with | risk of thrombosis *In ITP, Immune dysfunction characterized by ab formation against Platelet antigen. - Pt sequestration Coombs +ve, Hemolytic anemia -| platelet count - Bleeding

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