Which of the following antimicrobial is effective against on organism producing extended spectrum beta lactamase?
High-Yield Explanation
Tazobactam is a Beta-lactamase inhibitor similar to sulbactam. Its pharmacokinetics matches with piperacillin with which it has been combined for use in severe infections like peritonitis, pelvic/ urinary /respiratory infections caused by Beta-lactamase producing bacilli . However, the combination is not active against piperacillin-resistant Pseudomonas, because tazobactam (like clavulanic acid and sulbactam) does not inhibit inducible chromosomal Beta lactamase produced by Enterobacteriaceae. It is also of no help against Pseudomonas that develop resistance by losing permeability to piperacillin. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:703