Thiamine pyrophosphate is coenzyme required for all except rpt Q72

Thiamine pyrophosphate is the active form of thiamine. It serves as the coenzyme for the degradation or synthesis of alpha -ketols by trans ketolase (Figure 28.12A), and in the oxidative decarboxylation of a-keto acids (Figure 28.12B). A.Clinical indications for thiamine The oxidative decarboxylation of pyruvate and a-ketoglutarate, which plays a key role in energy metabolism of most cells, is paicularly impoant in tissues of the nervous system. In thiamine deficiency, the activity of these two dehydrogenase-catalyzed reactions is decreased, resulting in a decreased production of ATP and, thus, impaired cellular function. Ref: Lippincott, 5th edition, page no: 379