Roopa Devi, a 65-year-old female with lymph-node-positive breast cancer was treated with systemic chemotherapy. Four weeks later, she developed frequent urination, suprapubic pain, dysuria, and hematuria. Which of the following could have prevented this patient's condition?

(Ref: Katzung 11/e p942) The patient described in the question has henorrhagic cystitiws caus3d by drugs like cyclophosphamide and ifosfamide. Hemorrhagic cystitis during therapy with cyclophosphamide or ifosfamide is caused by the urinary excretion of the toxic metabolite acrolein. This can be preventede by aggressive hydration, bladder irrigation, and administration of mesna, a sulfhydryl compound that binds acroleinin the urine.