A 65 year old male patient presents with nonspecific symptoms, moderate splenomegaly. His lab tests shows a WBC count of 2000, a normal differential count, Hb 6, platelets 80,000 and 6% blast cells. What is the most likely diagnosis?

The clinical scenario and the lab tests ours the diagnosis of Acute myeloid leukemia. Acute myeloid leukemia: Patients with AML most often present with nonspecific symptoms that begin gradually or abruptly and are the consequence of anemia, leukocytosis, leukopenia or leukocyte dysfunction, or thrombocytopenia. Fever, splenomegaly, hepatomegaly, lymphadenopathy, sternal tenderness, and evidence of infection and hemorrhage are often found at diagnosis. Anemia is usually present at diagnosis and can be severe. Leukocyte count is about 15,000. Between 25 and 40% of patients have counts 100,000. Platelet counts <100,000/L are found at diagnosis. Abnormal rod-shaped granules called Auer rods are not uniformly present, but when they are, myeloid lineage is viually ceain. Ref: Harrison's Internal Medicine, 18th Edition, Pages 872-5, 887-92, 905-9, 968-69